X线致癌的可能性

2005年高居医患关心话题第5名(美国)

 

 

您现在的位置:医学求索网:医学新知报道:X线与肿瘤--儿童的风险最大

 

 

   

    这里是对医源性放射性影响进行地客观、公正的评价。

 

 

     JERRYDOCTOR 在译此文时发现,有时中文难以准确表达原文的意思,可能是我的英文不够好,也可能是我的中文不够好,或两者兼而有之。

    不过,我还知道,如果您读了很的英文原版教材后,也会发现大量诸如此类的问题。

    所以,我建议大家看我的译文时,如有疑问,就多读原文,这并不困难。而且,这样获得的知识可能更准确。

 

 

Imaging and Cancer: Kids Most in Peril

          The above being said, the indisputable fact, and in my opinion rendered truly indisputable by the BEIR VII report, is that medical x-rays cause cancer.[1] BEIR VII also emphasizes that there may be no safe lower limit.[1] This statement taken as said has the potential to cause considerable alarm, so my intuitive modification is that perhaps below the dose of a standard body CT, which is approximately 10 mSieverts (mSv; units that radiation dose is measured in), there is likely negligible if any risk for an individual test.

          However, even 1 body CT scan (1 CT scan of only 1 of the following regions: the chest region, the abdominal region, or the pelvic region) carries with it some element of risk. The risk that BEIR VII reports is 1 in 1000 chance of developing cancer from a 10 mSv radiation dose. In my prior report, I described what is written on the US Food and Drug Administration Web site, which is a 1 chance in 2000 of developing cancer from a dose of 10 mSv. The BEIR VII report doubles that risk. The risk in children is even higher, with a reported chance of 1 in 550 of developing cancer.[2,3] The following is a table of the standard reported dose of radiation for various common imaging procedures:

Diagnostic Examination

Effective Dose (mSv)

X-rays

   Chest (PA film)

0.02

   Head

0.07

   Cervical spine

0.3

   Thoracic spine

1.4

   Lumbar spine

1.8

   Abdomen

0.53

   Pelvis/hip

0.83

   Limbs/joints

0.06

   Upper GI

3.6

   Lower GI

6.4

   Screening mammogram

0.13

CT

   Head

2.0

   Abdomen

10.0

   Chest

20-40

   Pulmonary angiography

20-40

PET - CT

25

         Risk escalates with multiphase acquisition in a single CT study, and with multiple individual CT tests. Because of their multiphase nature, careful limited use of multiphase renal CT studies and liver CT studies should be considered.


X线成像和癌症:儿童的风险最大

      如标题所示,一个无可置疑的事实,以我观点在BEIR 7 报告中所述,医源性X线可以致癌。在BERIR 7也强调如果使用限制不足可能不安全。这种提法也意味着这个潜在的危险也造成不容忽视的警示(可能会造成不必要的惊慌),所以我的直觉修正是:大多数的标准的人体CT检查之低剂量,大约是10mSv(一种放射计量单位),对个体的风险几乎可以忽略不计。

       然而,即便1人体CT扫描检查(1CT扫描检查仅有以下1个区域:胸部、腹部、盆腔)负担有一些危险。在BEIR 7报告中提及因接受10mSv单位的放射剂量后发生致癌可能的机会是0.1%。在我更早些的报道中,如在US FDA网站上所言为0.05%。而在BEIR 7报道中增加了一倍。儿童中的风险可能更大,一个报道为致癌风险为 1/550 。下表为标准的各部位成像的报道放射剂量:

 

诊断检查项目

射线负担(mSv)

X线检查

胸部(PA位片)

0.02

头部

0.07

颈椎

0.3

胸椎

1.4

腰椎

1.8

腹部

0.53

盆腔/臀部

0.83

四肢/关节

0.06

上部GI

3.6

下部GI

6.4

乳房X线照片

0.13

CT

头部

2.0

腹部

10.0

胸部

20~40

肺部造影

20~40

PET-CT(正电子成像CT)

25

 

     在单一的CT研究和多个独立CT检验中,随着扫描部位的增加,致癌风险升高。因这个问题,特加应该注意认真限制多部位和多次的肾区CT检查以及肝脏的CT检查。

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